Integrated Approaches to Drug Discovery for Oxidative Stress-Related Retinal Diseases

Figure 1

Integrative approaches to identify therapeutic targets. Integration of multilevel omics data and biological knowledge allows construction of disease-related networks and the discovery of potential therapeutic targets (represented as cyan circles in the network). In vitro and in vivo disease models can be used to validate the therapeutic targets and drugs, and drugs displaying efficacy in preclinical models can then be moved into clinical trials.