Thioredoxin-Interacting Protein Mediates NLRP3 Inflammasome Activation Involved in the Susceptibility to Ischemic Acute Kidney Injury in Diabetes

Figure 3

RES treatment of STZ-induced diabetes ameliorates renal dysfunction and oxidative stress level. After RES administration for 7 consecutive days (daily ip 10 mg/kg RES), kidney tissues were collected for H&E staining and the histological damage score (a, c) and TUNEL assay of apoptosis (b, d). Blood samples for measuring BUN (e), serum creatinine (f), kidney tissues for analysis of SOD content (g) and MDA production (h), body weight (i), and plasma glucose (j) were examined. The data in (c–j) are means ± SE (). versus NS group; versus DS group. NS and DS: nondiabetic and STZ-induced diabetic rats were subjected to sham operation. NI/R and DI/R: nondiabetic and STZ-induced diabetic rats were subjected to 25 min ischemia followed by 48 h reperfusion. DS-RES: STZ-induced diabetic rats that underwent sham operation were treated with RES (10 mg/kg, ip daily) for 7 consecutive days.

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