Dietary Phenolic Compounds Interfere with the Fate of Hydrogen Peroxide in Human Adipose Tissue but Do Not Directly Inhibit Primary Amine Oxidase Activity

Figure 3

Inhibition of benzylamine-induced hydrogen peroxide release in human subcutaneous adipose tissue by reference MAO and SSAO inhibitors and by phenolic compounds. Fluorescence readouts after 30 min incubation were substracted from corresponding values at t0 and net increase was set at 100% for 1 mM benzylamine alone. (a) Pargyline (MAO, dark squares) or semicarbazide (SSAO inhibitor, open squares) was present at indicated final concentrations, while their combination was tested at 1 mM (P + S, black triangle). Mean ± SEM of at least 6 homogenates. (b) The phenolic compounds were tested in parallel at the indicated final concentrations. Means ± SEM of 8 to 12 homogenates.

(a)

(b)