Widening and Elaboration of Consecutive Research into Therapeutic Antioxidant Enzyme Derivatives

Figure 1

Dark areas at the top of bars demonstrate intervals of antithrombotic activities of various forms of SOD and CAT according to occlusion time (a) and thrombus mass (b). 1, control (normal saline); 2, mixture of native SOD and CAT; 3, mixture of native SOD and CAT with free CHS; 4, mixture of native SOD with CAT-CHS derivative; 5, mixture of SOD-CHS derivative with native CAT; 6, mixture of SOD-CHS and CAT-CHS derivatives; 7, SOD-CHS-CAT bienzyme derivative. Each combination of the derivatives was intravenously injected into rats with arterial thrombosis induced by ferric chlorine (saturated solution). The dose was similar to that for SOD-CHS-CAT conjugate (37 ± 3 U SOD and 80 ± 3 U CAT activities).

(a)

(b)