24-Week Exposure to Oxidized Tyrosine Induces Hepatic Fibrosis Involving Activation of the MAPK/TGF-<i>β</i>1 Signaling Pathway in Sprague-Dawley Rats Model

<div>HE stain of liver sections (×100). Hepatic photomicrographs of representative rats are shown from each of the five groups. (a) Control liver tissue. (b) Liver tissue of rats treated with O-Tyr (2 mg/mg). (c) Liver tissue of rats treated with O-Tyr (4 mg/mg). (d) Liver tissue of rats treated with O-Tyr (8 mg/mg). (e) Liver tissue of rats treated with Tyr (8 mg/mg).<i> Notes</i>. CV: central vein; LCC: hepatic cell cords; S: hepatic sinusoid; PA: portal area. The dotted lines denote infiltration of inflammatory cells; the solid lines suggest tissue fibrosis in portal area.</div>

Oxidative Medicine and Cellular Longevity

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Figure 6

Figure 6: 24-Week Exposure to Oxidized Tyrosine Induces Hepatic Fibrosis Involving Activation of the MAPK/TGF-<i>β</i>1 Signaling Pathway in Sprague-Dawley Rats Model 

Figure 6 | 24-Week Exposure to Oxidized Tyrosine Induces Hepatic Fibrosis Involving Activation of the MAPK/TGF-β1 Signaling Pathway in Sprague-Dawley Rats Model 