Neurodegeneration and Glial Response after Acute Striatal Stroke: Histological Basis for Neuroprotective Studies

Figure 3

Progressive astrocyte activation after striatal focal ischemia. Control animal injected with sterile saline (a-b) or ischemic animals injected with ET-1 at 3 (c-d), 7 (e-f), 14 (g-h), and 30 (i-j) PLDs. Maximum astrocyte activation occurred around 7 and 14 PLDs. The cell density was smaller at 7 and 14 PLDs. compared to others groups; compared to 7 and 14 PLDs. Arrows point to astrocytes in the higher power images. Scale bars: (a), (c), (e), (g), and (i) (100 μm) and (b), (d), (f), (h), and (j) (20 μm).