Neurodegeneration and Glial Response after Acute Striatal Stroke: Histological Basis for Neuroprotective Studies

Figure 7

Oligodendrocyte damage (Tau-1+ cells) and increased Nogo-A immunoreactivity after focal striatal ischemia. Control animals injected with sterile saline (a-b, l-m). Tau-1 and Nogo-A+ cells at 3 (c-d, n-o), 7 (e-f, p-q), 14 (g-h, r-s), and 30 (i-j, t-u) PLDs. Quantitative analysis showed maximum numbers of Tau-1 and Nogo-A+ cells at 3 PLDs (k, v). There is a long-lasting increase in the number of Nogo-A+ cells up to 30 PLDs compared to control (, ANOVA-Tukey). compared to control; compared to previous survival time. Scale bars: (a), (c), (e), (g), (i), (l), (n), (p), (r), and (t) (100 μm) and (b), (d), (f), (h), (j), (m), (o), (q), (s), and (u) (20 μm).