Evidence for Detrimental Cross Interactions between Reactive Oxygen and Nitrogen Species in Leber’s Hereditary Optic Neuropathy Cells

Figure 3

NO impairs the viability of 11778/ND4 mutated lymphoblasts. The cells derived from the LHON patient and the three healthy controls were treated with various concentrations of DETA-NONOate for 48 h and their viability was assessed using the MTT assay. Data are shown as the percentage of cell viability measured in the absence of the NO releaser. Data acquired in three triplicate experiments are expressed as mean ± SEM. Values are considered significant when : ; .