Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 3406802, 9 pages
http://dx.doi.org/10.1155/2016/3406802
Research Article

Protection of Pentoxifylline against Testis Injury Induced by Intermittent Hypobaric Hypoxia

1Organ Transplant Institute, Chinese PLA 309th Hospital, Beijing 100091, China
2Institute of Genetic Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China

Received 30 December 2015; Revised 21 March 2016; Accepted 21 April 2016

Academic Editor: Paloma B. Liton

Copyright © 2016 Chen Yao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. G. Farías, D. Jimenez, J. Osorio, A. B. Zepeda, C. A. Figueroa, and V. M. Pulgar, “Acclimatization to chronic intermittent hypoxia in mine workers: A challenge to mountain medicine in Chile,” Biological Research, vol. 46, no. 1, pp. 59–67, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. A. W. Bigham, X. Mao, R. Mei et al., “Identifying positive selection candidate loci for high-altitude adaptation in Andean populations,” Human Genomics, vol. 4, no. 2, pp. 79–90, 2009. View at Google Scholar · View at Scopus
  3. C. Caramelo, J. J. Peña Deudero, A. Castilla et al., “Response to hypoxia. A systemic mechanism based on the control of gene expression,” Medicina, vol. 66, no. 2, pp. 155–164, 2006. View at Google Scholar · View at Scopus
  4. J. G. Farías, A. B. Zepeda, and G. M. Calaf, “Melatonin protects the heart, lungs and kidneys from oxidative stress under intermittent hypobaric hypoxia in rats,” Biological Research, vol. 45, no. 1, pp. 81–85, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. C. J. Schofield and P. J. Ratcliffe, “Oxygen sensing by HIF hydroxylases,” Nature Reviews Molecular Cell Biology, vol. 5, no. 5, pp. 343–354, 2004. View at Publisher · View at Google Scholar
  6. J. G. Farias, E. Bustos-Obregón, R. Orellana, J. L. Bucarey, E. Quiroz, and J. G. Reyes, “Effects of chronic hypobaric hypoxia on testis histology and round spermatid oxidative metabolism,” Andrologia, vol. 37, no. 1, pp. 47–52, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. J. G. Farias, M. Puebla, A. Acevedo et al., “Oxidative stress in rat testis and epididymis under intermittent hypobaric hypoxia: protective role of ascorbate supplementation,” Journal of Andrology, vol. 31, no. 3, pp. 314–321, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. V. Verratti, F. Berardinelli, C. Di Giulio et al., “Evidence that chronic hypoxia causes reversible impairment on male fertility,” Asian Journal of Andrology, vol. 10, no. 4, pp. 602–606, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. G. F. Gonzales, “Serum testosterone levels and excessive erythrocytosis during the process of adaptation to high altitudes,” Asian Journal of Andrology, vol. 15, no. 3, pp. 368–374, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Sinha, A. Dutta, S. N. Singh, and U. S. Ray, “Protein nitration, lipid peroxidation and DNA damage at high altitude in acclimatized lowlanders and native highlanders: relation with oxygen consumption,” Respiratory Physiology and Neurobiology, vol. 171, no. 2, pp. 115–121, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Magalhães, A. Ascensão, J. M. C. Soares et al., “Acute and severe hypobaric hypoxia increases oxidative stress and impairs mitochondrial function in mouse skeletal muscle,” Journal of Applied Physiology, vol. 99, no. 4, pp. 1247–1253, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Álvarez, L. Tapia, L. A. Mardones, J. C. Pedemonte, J. G. Farías, and R. L. Castillo, “Cellular mechanisms against ischemia reperfusion injury induced by the use of anesthetic pharmacological agents,” Chemico-Biological Interactions, vol. 218, pp. 89–98, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Hemadi, S. Shokri, F. Moramezi, R. Nikbakht, and A. Sobhani, “Potential use of melatonin supplementation to protect vitrified testicular grafts from hypoxic-ischaemic damage,” Andrologia, vol. 46, no. 5, pp. 513–521, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. R. L. Castillo, A. B. Zepeda, S. E. Short, E. Figueroa, E. Bustos-Obregon, and J. G. Farías, “Protective effects of polyunsatutared fatty acids supplementation against testicular damage induced by intermittent hypobaric hypoxia in rats,” Journal of Biomedical Science, vol. 22, no. 1, article 8, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. B. Emrecan, E. Tulukoglu, S. Bozok et al., “Effects of Iloprost and pentoxifylline on renal ischemia-reperfusion in rabbit model,” European Journal of Medical Research, vol. 11, no. 7, pp. 295–299, 2006. View at Google Scholar · View at Scopus
  16. M. Stafford-Smith, “Evidence-based renal protection in cardiac surgery,” Seminars in Cardiothoracic and Vascular Anesthesia, vol. 9, no. 1, pp. 65–76, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Vadiei, L. J. Brunner, and D. R. Luke, “Effects of pentoxifylline in experimental acute renal failure,” Kidney International, vol. 36, no. 3, pp. 466–470, 1989. View at Publisher · View at Google Scholar · View at Scopus
  18. M. E. Dávila-Esqueda and F. Martínez-Morales, “Pentoxifylline diminishes the oxidative damage to renal tissue induced by streptozotocin in the rat,” Experimental Diabesity Research, vol. 5, no. 4, pp. 245–251, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. Z. Gunduz, O. Canoz, H. Per et al., “The effects of pentoxifylline on diabetic renal changes in streptozotocininduced diabetes mellitus,” Renal Failure, vol. 26, no. 6, pp. 597–605, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Ward and S. P. Clissold, “Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy,” Drugs, vol. 34, no. 1, pp. 50–97, 1987. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Zabel, F. U. Schade, and M. Schlaak, “Inhibition of endogenous TNF formation by pentoxifylline,” Immunobiology, vol. 187, no. 3–5, pp. 447–463, 1993. View at Publisher · View at Google Scholar · View at Scopus
  22. M. S. Petrovich, H. Y. Hsu, X. Gu, P. Dugal, K. B. Heller, and A. A. Sadun, “Pentoxifylline suppression of TNF-α mediated axonal degeneration in the rabbit optic nerve,” Neurological Research, vol. 19, no. 5, pp. 551–554, 1997. View at Google Scholar · View at Scopus
  23. A. W. Shindel, G. Lin, H. Ning et al., “Pentoxifylline attenuates transforming growth factor-β1-stimulated collagen deposition and elastogenesis in human tunica albuginea-derived fibroblasts part 1: impact on extracellular matrix,” Journal of Sexual Medicine, vol. 7, no. 6, pp. 2077–2085, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. O. M. E. Abdel-Salam, A. R. Baiuomy, S. M. El-Shenawy, and M. S. Arbid, “The anti-inflammatory effects of the phosphodiesterase inhibitor pentoxifylline in the rat,” Pharmacological Research, vol. 47, no. 4, pp. 331–340, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Xu, H. Lei, R. Guan et al., “Studies on the mechanism of testicular dysfunction in the early stage of a streptozotocin induced diabetic rat model,” Biochemical and Biophysical Research Communications, vol. 450, no. 1, pp. 87–92, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Bessler, R. Gilgal, M. Djaldetti, and I. Zahavi, “Effect of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphonuclear cells,” Journal of Leukocyte Biology, vol. 40, no. 6, pp. 747–754, 1986. View at Google Scholar · View at Scopus
  27. S. Endres, H.-J. Fulle, B. Sinha et al., “Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1 beta by human mononuclear cells,” Immunology, vol. 72, no. 1, pp. 56–60, 1991. View at Google Scholar · View at Scopus
  28. A. Chapelier, J. Reignier, M. Mazmanian et al., “Pentoxifylline and lung ischemia-reperfusion injury: application to lung transplantation,” Journal of Cardiovascular Pharmacology, vol. 25, pp. S130–S133, 1995. View at Publisher · View at Google Scholar · View at Scopus
  29. D. Seiffge, T. Bissinger, E. Kremer, V. Laux, and R. Schleyerbach, “Inhibitory effects of pentoxifylline on LPS-induced leukocyte adhesion and macromolecular extravasation in the microcirculation,” Inflammation Research, vol. 44, no. 7, pp. 281–286, 1995. View at Publisher · View at Google Scholar · View at Scopus
  30. V. B. Bhat and K. M. Madyastha, “Antioxidant and radical scavenging properties of 8-oxo derivatives of xanthine drugs pentoxifylline and lisofylline,” Biochemical and Biophysical Research Communications, vol. 288, no. 5, pp. 1212–1217, 2001. View at Publisher · View at Google Scholar · View at Scopus
  31. G. Ciuffetti, M. Mercuri, C. Ott et al., “Use of pentoxifylline as an inhibitor of free radical generation in peripheral vascular disease. Results of a double-blind placebo-controlled study,” European Journal of Clinical Pharmacology, vol. 41, no. 6, pp. 511–515, 1991. View at Publisher · View at Google Scholar · View at Scopus
  32. B. Horvath, Z. Marton, R. Halmosi et al., “In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine,” Clinical Neuropharmacology, vol. 25, no. 1, pp. 37–42, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. S.-L. Lin, Y.-M. Chen, C.-T. Chien, W.-C. Chiang, C.-C. Tsai, and T.-J. Tsai, “Pentoxifylline attenuated the renal disease progression in rats with remnant kidney,” Journal of the American Society of Nephrology, vol. 13, no. 12, pp. 2916–2929, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. M. A. Pozor, J. Muehlhaus, A. King, M. L. Macpherson, M. H. Troedsson, and C. S. Bailey, “Effect of pentoxifylline treatment on testicular perfusion and semen quality in Miniature horse stallions,” Theriogenology, vol. 76, no. 6, pp. 1027–1035, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. J. Tinkel, H. Hassanain, and S. J. Khouri, “Cardiovascular antioxidant therapy: a review of supplements, pharmacotherapies, and mechanisms,” Cardiology in Review, vol. 20, no. 2, pp. 77–83, 2012. View at Publisher · View at Google Scholar
  36. F. Erdemir, D. Atilgan, F. Firat, F. Markoc, B. S. Parlaktas, and E. Sogut, “The effect of Sertraline, Paroxetine, Fluoxetine and Escitalopram on testicular tissue and oxidative stress parameters in rats,” International Brazilian Journal Of Urology, vol. 40, no. 1, pp. 100–108, 2014. View at Publisher · View at Google Scholar · View at Scopus
  37. A. Jungwirth, A. Giwercman, H. Tournaye et al., “European association of urology guidelines on male infertility: the 2012 update,” European Urology, vol. 62, no. 2, pp. 324–332, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. H. B. Demopoulos, E. S. Flamm, D. D. Pietronigro, and M. L. Seligman, “The free radical pathology and the microcirculation in the major central nervous system disorders,” Acta Physiologica Scandinavica. Supplementum, vol. 492, pp. 91–119, 1980. View at Google Scholar
  39. S. C. Sikka, M. Rajasekaran, and W. J. G. Hellstrom, “Role of oxidative stress and antioxidants in male infertility,” Journal of Andrology, vol. 16, no. 6, pp. 464–468, 1995. View at Google Scholar · View at Scopus
  40. J. Meng, R. W. Holdcraft, J. E. Shima, M. D. Griswold, and R. E. Braun, “Androgens regulate the permeability of the blood-testis barrier,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 46, pp. 16696–16700, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. C. Savas, H. Dindar, A. Bilgehan, O. Ataoglu, and S. Yucesan, “Pentoxifylline attenuates reperfusion injury in testicular torsion,” Scandinavian Journal of Urology and Nephrology, vol. 36, no. 1, pp. 65–70, 2002. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Guven, M. Ickin, O. Uzun, C. Bakar, E. G. Balbay, and O. Balbay, “Erdosteine protects rat testis tissue from hypoxic injury by reducing apoptotic cell death,” Andrologia, vol. 46, no. 1, pp. 50–58, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. W. Liao, M. Cai, J. Chen et al., “Hypobaric hypoxia causes deleterious effects on spermatogenesis in rats,” Reproduction, vol. 139, no. 6, pp. 1031–1038, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. M. Cikutovic, N. Fuentes, and E. Bustos-Obregón, “Effect of intermittent hypoxia on the reproduction of rats exposed to high altitude in the Chilean Altiplano,” High Altitude Medicine and Biology, vol. 10, no. 4, pp. 357–363, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. O. N. Shevantaeva and Y. I. Kosyuga, “Effect of acute hypobaric hypoxia on spermatogenesis and lactate concentration in testicular tissue of male albino rats,” Bulletin of Experimental Biology and Medicine, vol. 141, no. 1, pp. 20–22, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. R. M. Sharpe, C. McKinnell, C. Kivlin, and J. S. Fisher, “Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood,” Reproduction, vol. 125, no. 6, pp. 769–784, 2003. View at Publisher · View at Google Scholar · View at Scopus
  47. H. H. N. Yan, D. D. Mruk, W. M. Lee, and C. Y. Cheng, “Ectoplasmic specialization: a friend or a foe of spermatogenesis?” BioEssays, vol. 29, no. 1, pp. 36–48, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. A. P. S. Hikim and R. S. Swerdloff, “Hormonal and genetic control of germ cell apoptosis in the testis,” Reviews of Reproduction, vol. 4, no. 1, pp. 38–47, 1999. View at Publisher · View at Google Scholar · View at Scopus
  49. Z. Q. Wang, Y. Watanabe, A. Toki, and T. Itano, “Altered distribution of sertoli cell vimentin and increased apoptosis in cryptorchid rats,” Journal of Pediatric Surgery, vol. 37, no. 4, pp. 648–652, 2002. View at Publisher · View at Google Scholar · View at Scopus
  50. M. S. Alam, S. Ohsako, T. W. Tay, N. Tsunekawa, Y. Kanai, and M. Kurohmaru, “Di(n-butyl) phthalate induces vimentin filaments disruption in rat sertoli cells: a possible relation with spermatogenic cell apoptosis,” Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia, vol. 39, no. 3, pp. 186–193, 2010. View at Publisher · View at Google Scholar · View at Scopus
  51. Y. Takada, X. Ye, and S. Simon, “The integrins,” Genome Biology, vol. 8, no. 5, article 215, 2007. View at Publisher · View at Google Scholar · View at Scopus