Cox-2 Inhibition Protects against Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis via Akt-Dependent Enhancement of iNOS Expression

Figure 2

Inhibition of COX-2 activity attenuates H/R-induced cell injury. (a) The COX-2 activity, (b) the release of LDH, and (c) cell viability in H9C2 cardiomyocytes with or without H/R treatment in the presence or absence of NS398 (COX-2 specific inhibitor, 10 μM, 1 h). COX-2 activity was expressed against that in H/R group. The LDH leakage and cell viability were expressed against those in CTL group. Data are shown as means ± SEM; CTL versus H/R or H/R + NS398, H/R versus H/R + NS398 (one-way ANOVA followed by Tukey’s test); per group.

(a)

(b)

(c)