Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice

Figure 5

Inflammasome expression and activation in the mouse heart. Representative western blotting showing cardiac levels of Nlrp3 (a), the best characterized element of inflammasome complex, and of downstream activation of caspase-1 (b) assessed on heart apex extracts from Control or HFHF diet mice, with or without IR. Histograms report densitometric analysis of 5-6 mice per group normalized, respectively, for the corresponding tubulin content or the procaspase-1 content. versus Control; versus Sham.

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