Inhibition of HSP90 Promotes Neural Stem Cell Survival from Oxidative Stress through Attenuating NF-κB/p65 Activation

Figure 3

H₂O₂ triggers HSP90 and NF-κB/p65 activation. (a) and (c) The protein expression of HSP90, nuclear phospho-p65, and total p65 in the NSCs induced by H₂O₂ induction. (b) and (d) The intracellular distribution of HSP90 and the nuclear translocation of phospho-p65 in the H₂O₂ induced NSCs. The protein expression and intracellular distribution in NSCs cultured within the vehicle medium were used as control. and were considered to be significantly different between control and H₂O₂ groups. n = 3.

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