Inhibition of HSP90 Promotes Neural Stem Cell Survival from Oxidative Stress through Attenuating NF-κB/p65 Activation

Figure 5

Effect of Geldanamycin on the colocalization in the H₂O₂ induced NSCs. (a) The protein distribution and colocalization of HSP90 and NF-B/p65 in control, H₂O₂ induced, and GA+H₂O₂ induced NSCs. (b) Percentage of phospho-p65 nuclear translocation in control, H₂O₂ induced, and GA+H₂O₂ induced NSCs. (c) Percentage of colocalization of HSP90 and NF-B/p65 in control, H₂O₂ induced, and GA+H₂O₂ induced NSCs. was considered to be significantly different between control and H₂O₂ groups or between H₂O₂ and DA+H₂O₂ groups. n = 3.

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