Protective Effects of Melatonin on Retinal Inflammation and Oxidative Stress in Experimental Diabetic Retinopathy

Figure 2

Effect of melatonin on antioxidant GSH and the enzyme GCL expressions in retinas from diabetic rats. (a) Measurement of glutathione contents by the DTNB method. The value from the retinas of the nondiabetic group was considered as 100% (control). (b–d) Western blot of GCL proteins in retinas from the study groups. Quantification data from the Western blot after normalizing to β-actin. and when compared with the ND group. ND, nondiabetic group. D8/D12, diabetic group at 8 and 12 weeks; DM8/DM12, melatonin-treated diabetic group at 8 and 12 weeks.

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