Bilateral Renal Denervation Ameliorates Isoproterenol-Induced Heart Failure through Downregulation of the Brain Renin-Angiotensin System and Inflammation in Rat

Table 3

The slopes of baroreflex function in control and heart failure rats with renal denervation (RD) and intracerebroventricular (icv) infusion of AT1-R antagonist irbesartan (Irbe) or of TNF-α inhibitor etanercept (ENT).

	Baroreflex slopes (/group)
	Sham + saline	RD + saline	Sham + ISO	RD + ISO	icv Irbe + ISO	icv ENT + ISO
PE	−8.15 ± 1.21	−7.46 ± 1.63	−1.85 ± 0.67^#	−4.69 ± 1.06	−5.38 ± 0.84	−3.87 ± 0.71
SNP	2.88 ± 0.63	2.56 ± 0.44	1.15 ± 0.25^#	1.31 ± 0.22^#	1.04 ± 0.13^#	1.15 ± 0.26^#

ISO, isoproterenol; PE, phenylephrine; SNP, sodium nitroprusside. versus Sham or RD + saline; versus Sham + ISO.