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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 3685671, 15 pages
Review Article

Phytochemicals and Biogenic Metallic Nanoparticles as Anticancer Agents

1Biotechnology Program, Faculty of Agro-Based Industry, Universiti Malaysia Kelantan, Campus Jeli, 17600 Jeli, Malaysia
2Department of Biochemistry, Sri Venkateswara Medical College, Tirupati, Andhra Pradesh 517502, India
3Department of Parasitology, Graduate School of Health Sciences, Kobe University, Kobe 654-0142, Japan
4Department of Fundamental and Applied Sciences, Universiti Teknologi Petronas, 32610 Tronoh, Malaysia
5Human Genome Centre, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia

Received 30 November 2015; Revised 5 January 2016; Accepted 24 January 2016

Academic Editor: Shreesh Ojha

Copyright © 2016 Pasupuleti Visweswara Rao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cancer is a leading cause of death worldwide. Several classes of drugs are available to treat different types of cancer. Currently, researchers are paying significant attention to the development of drugs at the nanoscale level to increase their target specificity and to reduce their concentrations. Nanotechnology is a promising and growing field with multiple subdisciplines, such as nanostructures, nanomaterials, and nanoparticles. These materials have gained prominence in science due to their size, shape, and potential efficacy. Nanomedicine is an important field involving the use of various types of nanoparticles to treat cancer and cancerous cells. Synthesis of nanoparticles targeting biological pathways has become tremendously prominent due to the higher efficacy and fewer side effects of nanodrugs compared to other commercial cancer drugs. In this review, different medicinal plants and their active compounds, as well as green-synthesized metallic nanoparticles from medicinal plants, are discussed in relation to their anticancer activities.