SOD1 Overexpression Preserves Baroreflex Control of Heart Rate with an Increase of Aortic Depressor Nerve Function

Figure 1

Original recordings of heart rate responses to pulse arterial pressure changes (PAP) induced by the sequential administration of SNP/PE in representative C57 and SOD1 animals. A tachycardiac phase was induced by a baroreflex-mediated increase in heart rate in response to decreased blood pressure due to SNP infusion. A bradycardic phase was induced by a baroreflex-mediated decrease in heart rate in response to increased blood pressure caused by injection of PE. During SNP application, MAP and HR changes from the baseline of MAP to the nadir of MAP were measured as shown in the light gray box. During PE application, MAP and HR changes were measured from the peak of the HR to the nadir of the HR as shown in the dark gray box.