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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 3831071, 8 pages
http://dx.doi.org/10.1155/2016/3831071
Clinical Study

Oxidative Stress in Children with Chronic Spontaneous Urticaria

1Department of Pediatric Allergy and Immunology, Bezmialem Vakif University Medical Faculty, Adnan Menderes Bulvari, Vatan Caddesi, Fatih, 34093 Istanbul, Turkey
2Department of Pediatric Allergy and Immunology, Istanbul University Istanbul Medical Faculty, Fatih, Capa, 34093 Istanbul, Turkey
3Department of Pediatrics, Istanbul Bilim University, Buyukdere Caddesi No. 120, Esentepe, Sisli, 34394 Istanbul, Turkey
4Department of Clinical Biochemistry, Bezmialem Vakif University Medical Faculty, Adnan Menderes Bulvari, Vatan Caddesi, Fatih, 34093 Istanbul, Turkey

Received 8 January 2016; Revised 9 March 2016; Accepted 14 March 2016

Academic Editor: Francisco J. Romero

Copyright © 2016 Fatih Dilek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The pathogenesis of chronic spontaneous urticaria (CSU) has not been fully understood; nevertheless, significant progress has been achieved in recent years. The aim of this study was to investigate the possible role of reactive oxygen species (ROS) in the pathogenesis of CSU. Sixty-two children with CSU and 41 healthy control subjects were enrolled in the study. An extensive evaluation of demographic and clinical features was done, and serum oxidative stress was evaluated by plasma total oxidant status (TOS) and total antioxidant status (TAS) measurements. The median value of plasma TOS was found to be 10.49 μmol H2O2 equiv./L (interquartile range, 7.29–17.65) in CSU patients and 7.68 μmol H2O2 equiv./L (5.95–10.39) in the control group. The difference between the groups was statistically significant (). Likewise, the median plasma TAS level in the CSU group was decreased significantly compared to that of the control group (2.64 [2.30–2.74] versus 2.76 [2.65–2.86] mmol Trolox equiv./L, resp., = 0,001). Our results indicated that plasma oxidative stress is increased in children with CSU when compared to healthy subjects, and plasma oxidative stress markers are positively correlated with disease activity.