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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 3837623, 13 pages
Research Article

Regular and Moderate Exercise Counteracts the Decline of Antioxidant Protection but Not Methylglyoxal-Dependent Glycative Burden in the Ovary of Reproductively Aging Mice

1Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy
2Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
3Department of Biomedical Sciences, “G. d’Annunzio” University, Via dei Vestini, Chieti Scalo, Italy
4Institute of Translational Pharmacology (IFT), National Research Council (CNR), L’Aquila, Italy

Received 9 October 2016; Revised 17 November 2016; Accepted 7 December 2016

Academic Editor: Mauricio Krause

Copyright © 2016 S. Falone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Population aging results in urgent needs of interventions aimed at ensuring healthy senescence. Exercise often results in healthy aging, yet many molecular mechanisms underlying such effects still need to be identified. We here investigated whether the age-dependent accumulation of oxidative and methylglyoxal- (MG-) related molecular damage could be delayed by moderate exercise in the mouse ovary, an organ that first exhibits impaired function with advancing age in mammals. CD1 female mice underwent two- or four-month treadmill-based running through the transition from adult to middle age, when ovaries show signs of senescence, and markers of protection against reactive oxygen species (ROS) and MG were measured. The long-term exercise reduced the protein oxidative damage in the ovaries (), and this was linked to the preservation of the glutathione peroxidase protection against ROS (), as well as to the increased glutathione availability (). Conversely, even though the age-related deactivation of the MG-targeting systems was partially prevented by the long-term running programme (), exercised mice were not protected from the age-dependent glycative burden. In summary, lately initiated regular and moderate exercise limited some changes occurring in the ovaries of middle-aged mice, and this might help to develop nonpharmacological cointerventions to reduce the vulnerability of mammalian ovaries towards redox dysfunctions.