Modulation of Hypercholesterolemia-Induced Oxidative/Nitrative Stress in the Heart

Figure 1

Hypercholesterolemia-induced myocardial oxidative/nitrative stress and its possible modulations (in grey boxes) to prevent or treat deleterious cardiac consequences. Ac-CoA: acetyl-coenzyme A; HMG-CoA: 3-hydroxy-3-methyl glutaryl coenzyme A; eNOS: endothelial nitric oxide synthase; ONOO⁻: peroxynitrite; ROS: reactive oxygen species; RNS: reactive nitrogen species; miRNA: microRNA.