The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression

Table 3

NFκB-dependent genes and their role in tumorigenesis.

NFκB-dependent gene families	Proinflammatory phenotype; and malignancy hallmark	ROS effect	References
Inducible enzymes	Vasodilatation, migration	Indirect	[87–89]
Cytokines and receptors	Local amplification of IRR	Direct and indirect	[90–94]
MMPs and TIMPs	Invasion, migration	Direct and indirect	[97–100]
Adhesion molecules and their counterreceptors	Detachment, homing	Indirect	[101–103]
Chemokines and receptors	Migration, homing	Direct and indirect	[104, 105]
VEGFs and VEGFRs	Angiogenesis, repair	Indirect	[63–65, 106]
Growth and survival factors	Proliferation, antiapoptosis, repair	Indirect	[107, 108]
Acute-phase proteins	IRR amplification, chemotaxis, repair	Indirect	[109–113]
SOCS-1	Negative regulator of IRR	Indirect	[114–116]