Hyperglycemia Aggravates Hepatic Ischemia Reperfusion Injury by Inducing Chronic Oxidative Stress and Inflammation

Figure 8

The proposed mechanisms of hyperglycemia induced aggravation of HIRI. Chronic oxidative stress represented by generation of ROS was induced by excessive glucose. The amplified inflammation may be attributed to NF-κB translocation most probably induced by chronic oxidative stress. Hampered antioxidative ability of Nrf2 pathway may also be involved in aggravated HIRI after high glucose exposure. The potential inhibitory interaction between NF-κB and Nrf2 at transcription level may be a possible explanation.