Virus Infections on Prion Diseased Mice Exacerbate Inflammatory Microglial Response

Table 3

CA1 microglial numbers from pyramidal cell layer from animals injected with normal brain homogenate (NBH) or NBH followed by Piry intranasal injection or with ME7 infected brain homogenate (ME7) or by ME7 followed by Piry virus intranasal injection.

Stratum pyramidale of CA1
Subjects		Thickness (μm)	CE (Scheaffer)
NBH
NBHVII-2	3681	28.5	0.05
NBHVII-3	2200	19.2	0.06
NBHVII-4	3357	19.2	0.05
Mean	3080	22.3	0.05
SD	779
CV^2	0.064
CE^2	0.003
CE^2/CV^2	0.041
CVB^2	0.061
CVB^2 (% CV^2)	95.9
NBH+VIRUS
NBHV-3	3412.64	18.7	0.04
NBHVI-1	2506.66	15.1	0.05
NBHVI-2	2094.18	18.2	0.05
NBHVI-4	3634.26	18.1	0.05
Mean	2912	17.5	0.05
SD	732
CV^2	0.063
CE^2	0.002
CE^2/CV^2	0.035
CVB^2	0.061
CVB^2 (% CV^2)	96.5
ME7
ME7IX-1	5631	22.5	0.04
ME7IX-4	4749	15.9	0.04
ME7X-2.	5625	20	0.04
ME7X-4	3507	24.1	0.05
Mean	4878	21	0.04
SD	1003
CV^2	0.042
CE^2	0.002
CE^2/CV^2	0.045
CVB^2	0.040
CVB^2 (% CV^2)	95.5
ME7+VIRUS
ME7VII-1	10834	22.1	0.04
ME7VII-4	7375	15.3	0.03
ME7VIII-1	10240	23.8	0.04
ME7VIII-4	6202	20.5	0.04
Mean	8663	20.4	0.04
SD	2230
CV^2	0.066
CE^2	0.001
CE^2/CV^2	0.022
CVB^2	0.065
CVB^2 (% CV^2)	97.8

CVB² = (CV, coefficient of variation; CE, Scheaffer coefficient of error; CVB, biological variation coefficient).