Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury

Figure 4

Antioxidant intervention opposes blast-induced hyperphosphorylation of Tau in the hippocampus. Representative images of hyperphosphorylated Tau (AT8) immunostaining in the dentate gyrus of the hippocampus from normal controls ((a), (d)), blast-exposed rats seven days after injury ((b), (e)), and antioxidant-treated rats seven days after blast ((c), (f)). The rectangles in (a)–(c) indicate the locations from which images were collected for (d)–(f), respectively. AT8-positive cells are denoted by arrows in (b)-(c) and (e)-(f). Scale bars = 200 μm in (c) for (a)–(c) and = 20 μm in (f) for (d)–(f).

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