Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury

Figure 6

The blast-induced accumulation of pathologic Tau oligomers in the hippocampus is reduced by antioxidant intervention. Representative images of oligomeric Tau (T22) immunostaining in the dentate gyrus of the hippocampus from normal controls ((a), (d), and (g)), in blast-exposed rats seven days after injury ((b), (e), and (h)) and in antioxidant-treated rats seven days after blast ((c), (f), and (i)). The rectangles in (a)–(c) indicate the locations from which images were collected for (d)–(i). T22-positive cells are denoted by arrows. Scale bars = 200 μm in (c) for (a)–(c) and = 20 μm in (i) for (d)–(i).

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