Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury

Figure 8

Tau accumulates in hippocampal cells in response to bTBI seven days after blast exposure. Representative images of AT8 and GluR2/3 ((a)–(d)), oligomeric Tau (T22) and AT8 ((e)–(h)) fluorescent immunolabeling in the PoDG of the hippocampus. In untreated rats, virtually AT8-positive cells in the hippocampus exhibited colabeling with the GluR2/3 antibody, identifying them as Mossy cells (arrow in (d)) while some AT8 positive cells were not colabeled with the GluR2/3 antibody (arrowhead in (d)). T22-positive cells in the hippocampus exhibited colabeling with the AT8 antibody (arrows in (e) and (h)). Scale bar in (h) = 10 μm for (a)–(h).

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