Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants

Figure 2

Redox-active substances and cancer. A variety of redox-active substances (direct or indirect antioxidants) are known to exhibit cancer chemopreventive properties. In the pharmacological anticancer protocols, redox-active agents could be used as direct anticancer chemotherapeutics or synergies with cytotoxic effects of conventional anticancer drugs. Here, we discuss the feasibility of such substances in suppression/reversal of acquired MDR. The redox agents are often used for the protection of normal tissues/organs against toxic effects of chemotherapy and radiotherapy.