Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants

Figure 3

Antioxidant and prooxidant systems as molecular targets for redox-active MDR modulators. Glutathione and enzymes involved in the glutathione metabolism such as glutathione reductase (GR) and glutathione peroxidase (Gpx) as well as gamma-glutamyl cysteine ligase, catalase, NADPH-oxidase, thioredoxin (Trx), and peroxiredoxins (Prx) are potential molecular targets for future MDR modulators.