ROS and ROS-Mediated Cellular Signaling

Figure 6

Cross talk between ROS and Ca²⁺. IP3R, inositol 1,4,5-trisphosphate receptor; RyR, the ryanodine receptor; VDCC, voltage-dependent Ca²⁺ channels; SOC, store-operated Ca²⁺ channel; SERCA, sarcoplasmic/endoplasmic reticulum Ca²⁺ ATPase; PMCA, plasma membrane Ca²⁺ ATPase; MCU, mitochondrial Ca²⁺ uniporter; TCA cycle, tricarboxylic acid cycle; NCX, Na⁺/ Ca²⁺ exchanger.