Research Article
Monoamine Oxidase Is Overactivated in Left and Right Ventricles from Ischemic Hearts: An Intriguing Therapeutic Target
Table 1
Clinical characteristics of the patients.
| | | NF | IHD | Non-IHD |
| | Total number | 7 | 13 | 8 | | Sex (M/F) | 5/2 | 12/1 | 7/1 | | Age (range) | 52 (45–56) | 55 (37–69) | 45 (27–63) | | LVEF (%) | | 27 ± 3.8 | 23 ± 2.5 | | PAP (mmHg) | | 38 ± 3.2 | 29 ± 5.4 | | PCWP (mmHg) | | 23 ± 3 | 21 ± 5.4 | | RAP (mmHg) | | 14 ± 4 | 11 ± 4.4 | | NYHA class | | III-IV | III-IV | | Diuretics | | 7 | 5 | | Digoxin | | 0 | 2 | | Antiarrhythmics | | 3 | 2 | | ACE-I | | 10 | 5 | | β-blockers | | 7 | 5 | | Nitrates | | 4 | 0 | | Statins | | 2 | 0 | | ANF/rRNA 18S | 1.03 ± 0.001 | 12.4 ± 1.05 | 12.3 ± 0.98 | | MCH-α/rRNA 18S | 1.30 ± 0.03 | 0.06 ± 0.01 | 0.04 ± 0.002 | | MCH-β/rRNA 18S | 1.35 ± 0.2 | 0.06 ± 0.02 | 0.54 ± 0.05 |
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LVEF: left ventricular ejection fraction; ACE-I: angiotensin converting enzyme inhibitors; PCWP: pulmonary capillary wedge pressure; PAP: pulmonary artery pressure; RAP: right atrium pressure; HMGCoA inhibitors (statins); ANF: atrial natriuretic factor; MHC: myosin heavy chain.
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