The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity

Figure 6

Overexpression of TFEB rescues dopaminergic neurons of the SN in MPTP-treated mice. (a) GFP or TFEB adenovirus expression in the SN is shown in the figure. Cryosections were immunostained for GFP (green) or tyrosine hydroxylase (red). (b) TH immunohistochemistry showing DA neurons in the GFP and TFEB groups. The numbers of TH-positive neurons were compared with those on the uninjected side. The quantified data are shown in the histogram. Values are the means ± SEM. compared with the GFP group.

(a)

(b)