Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes

Figure 2

Histopathological analysis. Mesangial matrix index, images of histopathological glomerular changes, and quantitative analysis (a). Kidney sections show mild but noticeable increase in mesangial PAS positive area in diabetes (D) in comparison with control (C). Treatment with MMF demonstrates a reduction in the mesangium (DMMF). Interstitial fibrosis, kidney cortical sections, and quantitative analysis (b). Images show very thin red lines surrounding tubular epithelium (interstitium) in control (C), an increase in the space occupied by interstitium in diabetes (D), and finally a mild decrease in tubular interstitium in diabetes MMF-treated (DMMF). Original magnifications 200x. versus C; versus D.

(a)

(b)