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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 4729192, 14 pages
Review Article

Redox Modulations, Antioxidants, and Neuropsychiatric Disorders

1Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada M5T 1R8
2Department of Pharmacology, University of Toronto, Medical Science Building, 1 King’s College Circle, Toronto, ON, Canada M5S 1A8
3Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON, Canada M5T 1R8

Received 8 May 2015; Accepted 14 June 2015

Academic Editor: Ioannis P. Trougakos

Copyright © 2016 Erik A. Fraunberger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although antioxidants, redox modulations, and neuropsychiatric disorders have been widely studied for many years, the field would benefit from an integrative and corroborative review. Our primary objective is to delineate the biological significance of compounds that modulate our redox status (i.e., reactive species and antioxidants) as well as outline their current role in brain health and the impact of redox modulations on the severity of illnesses. Therefore, this review will not enter into the debate regarding the perceived medical legitimacy of antioxidants but rather seek to clarify their abilities and limitations. With this in mind, antioxidants may be interpreted as natural products with significant pharmacological actions in the body. A renewed understanding of these often overlooked compounds will allow us to critically appraise the current literature and provide an informed, novel perspective on an important healthcare issue. In this review, we will introduce the complex topics of redox modulations and their role in the development of select neuropsychiatric disorders.