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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 4848015, 9 pages
http://dx.doi.org/10.1155/2016/4848015
Research Article

Effects of 12-Week Endurance Training at Natural Low Altitude on the Blood Redox Homeostasis of Professional Adolescent Athletes: A Quasi-Experimental Field Trial

1Department of Physical Education, Dr. Stephen Hui Research Centre for Physical Recreation and Wellness, Hong Kong Baptist University, Hong Kong
2Faculty of Education, University of Macau, Macau
3College of Physical Education, Liaoning Normal University, Dalian, Liaoning 116029, China
4Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, 43126 Parma, Italy
5School of Physical Education and Sports, Macao Polytechnic Institute, Macau
6College of Physical Education, Hebei Normal University, Shijiazhuang, Hebei 050024, China

Received 1 July 2015; Revised 27 August 2015; Accepted 31 August 2015

Academic Editor: Vincent Pialoux

Copyright © 2016 Tomas K. Tong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This field study investigated the influences of exposure to natural low altitude on endurance training-induced alterations of redox homeostasis in professional adolescent runners undergoing 12-week off-season conditioning program at an altitude of 1700 m (Alt), by comparison with that of their counterparts completing the program at sea-level (SL). For age-, gender-, and Tanner-stage-matched comparison, 26 runners ( in each group) were selected and studied. Following the conditioning program, unaltered serum levels of thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (T-AOC), and superoxide dismutase accompanied with an increase in oxidized glutathione (GSSG) and decreases of xanthine oxidase, reduced glutathione (GSH), and GSH/GSSG ratio were observed in both Alt and SL groups. Serum glutathione peroxidase and catalase did not change in SL, whereas these enzymes, respectively, decreased and increased in Alt. Uric acid (UA) decreased in SL and increased in Alt. Moreover, the decreases in GSH and GSH/GSSG ratio in Alt were relatively lower compared to those in SL. Further, significant interindividual correlations were found between changes in catalase and TBARS, as well as between UA and T-AOC. These findings suggest that long-term training at natural low altitude is unlikely to cause retained oxidative stress in professional adolescent runners.