Thioredoxin Binding Protein-2 Regulates Autophagy of Human Lens Epithelial Cells under Oxidative Stress via Inhibition of Akt Phosphorylation

Figure 7

TBP-2’s influence on autophagy is independent of the phosphorylation of mTOR but regulated by Akt. (a–c) Overexpression of TBP-2 inhibited Akt phosphorylation at Ser473 under oxidative stress (). Phosphorylation of mTOR at Ser2448 showed no difference. (d–f) Knockdown of TBP-2 increased Akt phosphorylation rate (). Phosphorylation of mTOR at Ser2448 also showed no difference. Data were presented as mean ± SEM of three independent experiments. . .

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