Memory Deficit Recovery after Chronic Vanadium Exposure in Mice

Figure 5

Effect of intermittent vanadium (VAN) treatment for twelve months on learning and memory in mice: 12 male mice each were exposed thrice a week for three, six, nine, and twelve months to VAN (3 mg/kg b.w.) with equal number and age matched controls. The withdrawal group were exposed to VAN for three months but replaced with water thereafter. All the groups of 3–12-month-old mice were subjected to forelimb grip test with 6–12 months reported here. There was no significant difference in latency to fall in the forelimb grip test between vanadium-exposed groups and their respective controls in all age groups. There was a significant reduction in latency to fall in vanadium withdrawal group W6 () relative to their controls.