Juglanthraquinone C Induces Intracellular ROS Increase and Apoptosis by Activating the Akt/Foxo Signal Pathway in HCC Cells

Figure 7

A proposed model to illustrate mechanisms by which JC induced the apoptosis of HCC cells. Akt hyperactivation caused by JC-inhibited Foxo transcriptional activity, which resulted in highly increased ROS levels via impairment of ROS scavenging. The upregulation of ROS, in turn, promoted apoptosis of HepG2 and BEL-7402 cells.