Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation
Table 1
Biochemical parameters of aqueous humor on day 8 of uveitis in rabbits.
Biochemical parameter
Treatment
Control
Placebo
SOD1
Nanozyme
Total protein concentration, mg/mL
2.2 ± 0.3
19.3 ± 3.2
15.6 ± 2.3
10.5 ± 1.1
α2-Macroglobulin, arb. U/mL
0.6 ± 0.1
10.8 ± 1.0
8.7 ± 1.5
7.2 ± 1.6
Antioxidant activity, U/mL
14.4 ± 1.0
2.3 ± 0.9
3.3 ± 0.6
3.7 ± 0.2
SOD1 activity, trolox-equivalents/mL
280 ± 40
460 ± 100
370 ± 80
330 ± 50
Significant difference between nanozyme and placebo by the Mann-Whitney U test, ; Significant difference between nanozyme and placebo, and nanozyme and native SOD1 by the Mann-Whitney U test, .
