Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge

Table 2

Hydrophilic components from Salvia miltiorrhiza that modify ROS-related effects on cancer cells.

Components [reference]	Cancer cells	Effects
Salvianolic acid A [51]	MCF-7 breast cancer cells	Downregulates the level of P-glycoprotein and triggers apoptosis, which is associated with increased caspase-3 activity, disrupted mitochondrial membrane potential, downregulated Bcl-2 expression, and upregulated Bax expression in resistant cells
Salvianolic acid A [52]	Human neuroblastoma SH-SY5Y cells	Prevents 1-methyl-4-phenylpyridinium ion-induced cytotoxicity, which may be ascribed to its antioxidant properties and antiapoptotic activity via regulating the expression of Bcl-2 and Bax
Salvianolic acid B [53]	Human glioma U87 cells	Induces apoptosis through p38-mediated ROS generation
Salvianolic acid B [54]	Human neuroblastoma SH-SY5Y cells	Prevents 1-methyl-4-phenylpyridinium-induced apoptosis by relieving oxidative stress and modulating the apoptotic process
Salvianolic acid B [55]	Human neuroblastoma SH-SY5Y cells	Prevents dopamine-induced apoptosis that may be mediated by the ROS and the Erk and Bcl-2 pathways