Notch1 Pathway Protects against Burn-Induced Myocardial Injury by Repressing Reactive Oxygen Species Production through JAK2/STAT3 Signaling

Figure 6

Notch signal blockade attenuates MnSOD and JAK2/STAT3 activation during burn injury. Rat cardiomyocytes were challenged with burn serum in vitro in the presence of DMSO or GSI. MnSOD (a) and JAK2/STAT3 (c, d) expression was determined by western blot in cardiomyocytes. MnSOD (b) and JAK2/STAT3 (e, f) expression in myocardial tissues of RBP-JKO and control mice subjected to burn injury for 12 hours. The values presented are the mean ± SEM ( per group). .

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