Oxidative Medicine and Cellular Longevity / 2016 / Article / Tab 4

Research Article

Changes in Oxidative Stress and Inflammatory Biomarkers in Fragile Adults over Fifty Years of Age and in Elderly People Exclusively Fed Enteral Nutrition

Table 4

Plasma cardiovascular and inflammatory biomarkers of frail adult and elderly patients fed exclusively by enteral nutrition with the experimental and reference diets for 90 d and 180 d.

ExperimentalReference
Baseline ()90 d ()180 d ()Baseline ()90 d ()180 d ()

MMP-9 (ng/mL)156.6 ± 20.5112.6 ± 17.769.7 ± 8.6121.1 ± 12.981.4 ± 13.461.0 ± 8.6
sVCAM-1 (μg/mL)1.07 ± 0.051.13 ± 0.081.34 ± 0.091.07 ± 0.081.08 ± 0.091.06 ± 0.10
sICAM-1 (ng/mL)211.6 ± 12.6214.3 ± 12.8253.9 ± 23.0199.6 ± 9.59204.0 ± 11.1189.6 ± 7.8
sE-Selectin (ng/mL)16.59 ± 1.416.8 ± 1.317.4 ± 3.316.23 ± 1.215.6 ± 1.816.6 ± 1.7
MCP-1 (pg/mL)202.0 ± 16.2174.8 ± 16.9161.6 ± 16.5173.5 ± 13.4144.6 ± 8.8152.5 ± 20.5
Endothelin-1 (pmol/L)2.22 ± 0.901.66 ± 0.941.80 ± 1.092.07 ± 0.501.84 ± 0.452.32 ± 0.95
tPAI-1 (ng/mL)10.32 ± 2.268.76 ± 2.495.08 ± 1.417.44 ± 1.988.01 ± 2.308.63 ± 2.05
MPO (ng/mL)21.76 ± 4.117.2 ± 3.014.3 ± 1.716.1 ± 2.116.7 ± 3.921.3 ± 3.8
TNFα (ng/mL)7.06 ± 0.927.29 ± 1.696.52 ± 0.795.60 ± 0.614.87 ± 0.554.72 ± 0.55
IL-6 (pg/mL)35.1 ± 6.540.0 ± 8.620.6 ± 7.535.8 ± 11.754.7 ± 18.640.2 ± 19.4
hsCRP (mg/L)2.03 ± 0.422.12 ± 0.650.98 ± 0.322.02 ± 0.591.88 ± 0.601.88 ± 0.55

Significant differences between groups at each time point. Significant differences time per group according to a general lineal model for repeated measures. Mean values within a row with unlike superscript letters are significantly different in each group. < 0.05 was considered significant. IL-6, interleukin-6; MCP-1, monocyte chemoattractant protein-1; MMP-9, metalloproteinase-9; MPO, myeloperoxidase; sICAM-1, soluble intercellular adhesion molecule-1; sVCAM-1, soluble vascular cell adhesion molecule-1; TNF-, tumour necrosis factor-; tPAI-1, total plasminogen activator inhibitor-1; hsCRP, high sensitive C reactive protein.

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