The Cellular Response to Oxidatively Induced DNA Damage and Polymorphism of Some DNA Repair Genes Associated with Clinicopathological Features of Bladder Cancer

Figure 3

Distribution of some genotypes/alleles of DNA repair genes in non-muscle-invasive and muscle-invasive tumors depending on their grades. (a) The frequencies of XPD Asp312Asn polymorphisms in low grade tumors (227 samples) as compared to high grade neoplasms (59 samples) as well as in low grade tumors (24 samples) as opposed to high grade neoplasms (97 samples). In the latter case, the frequencies of the Asp/Asp, Asn/Asn, and Asn/Asn+Asp/Asn genotypes and the Asn alleles were as follows: 50% and 28.9% (), 8.3% and 20.6% (), 50% and 71.1% (), and 29.2% and 45.9% () in low grade and high grade tumors, respectively. (b) The frequencies of XPD (codon 751) and ERCC6 (codon 399) polymorphisms in low grade tumors (24 samples for each polymorphisms) as compared to high grade neoplasms (95 and 97 samples, resp.).

(a)

(b)