Cardioprotective Potentials of Plant-Derived Small Molecules against Doxorubicin Associated Cardiotoxicity

Table 1

Phytochemicals investigated for cardioprotective activity against DOX-induced cardiotoxicity in in vivo studies.

Phytochemical	DOX-induced cardiomyopathy-animal model (acute or chronic)	Cardiac function determined (yes/no)	References
Arjunolic acid	Chronic	Yes	[13]
Berberine	Chronic	Yes	[20]
Berberine	Acute	Yes	[19]
Baicalein	Chronic	No	[23]
Caffeic acid phenethyl ester	Acute	Yes	[25]
Cannabidiol	Acute	Yes	[30]
Cannabidiol	Chronic	No	[29]
Carotenoids	Acute	No	[34]
Eugenol	Acute	Yes	[51]
Gingerol	Chronic	No	[56]
23-Hydroxybetulinic acid	Chronic	Yes	[60]
Hesperetin	Chronic	No	[64]
Hesperidin	Acute	No	[62]
Isorhamnetin	Chronic	No	[66]
Indole-3-carbinol	Chronic	No	[67]
Kaempferol	Chronic	No	[69]
Lycopene	Acute	No	[70]
Lycopene	Acute	No	[71]
Lycopene	Acute	Yes	[72]
Mangiferin	Acute	No	[79]
Mangiferin	Acute	No	[78]
Naringenin	Acute	No	[79]
Naringenin	Acute	No	[80]
Ocotillol	Acute	No	[86]
Ocotillol	Chronic	No	[86]
Hydroxytyrosol	Chronic	No	[65]
Tetrandrine	Chronic	Yes	[140]
Periplogenin	Chronic	No	[92]
p-coumaric acid	Acute	No	[82]
Procyanidins	Chronic	Yes	[100]
Robinin	Acute	No	[114]
Thymoquinone	Acute	No	[137]
Thymoquinone	Acute	No	[138]
Silibinin	Chronic	Yes	[126]
Sesamin	Acute	No	[124]
Sesamol	Chronic	No	[125]
Tetrahydroxystilbene glucoside	Acute	No	[135]
Oleuropein	Acute	No	[87]
Oleuropein	Acute	No	[88]
Oleuropein	Chronic	Yes	[89]
Frederine	Acute	Yes	[52]
Visnagin	Acute	Yes	[146]
Visnagin	Chronic	Yes	[146]
Schisandrin B	Acute	Yes	[121]
Schisandrin B	Chronic	Yes	[122]
Salvianolic acid A	Acute	Yes	[117]
Tanshinone IIA	Chronic	Yes	[133]
Oleuropein	Acute	No	[87]
Oleuropein	Acute	No	[88]
Oleuropein	Chronic	Yes	[89]
Frederine	Acute	Yes	[52]
Visnagin	Acute	Yes	[146]
Visnagin	Chronic	Yes	[146]
Schisandrin B	Acute	Yes	[121]
Schisandrin B	Chronic	Yes	[122]
Salvianolic acid A	Acute	Yes	[117]
Tanshinone IIA	Chronic	Yes	[133]