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Phytochemical | Concentration of the phytochemical | Cell culture model | DOX dose and time of incubation | References |
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Arjunolic acid | 100 μg/mL | Neonatal rat cardiomyocytes | 1 μM for 12 h | [13] |
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Apigenin | 25–100 µM | Rat heart cardiomyocytes | 100 µM for 8 h | [16] |
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Avicularin | 10–80 μM | H9c2 cells | 20 μM for 24 h | [17] |
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Berberine | 0.06, 0.25, 1.0, and 4.0 µM | Neonatal rat cardiomyocytes and MCF-7 cells | 1 µM for 2 h | [19] |
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Baicalein | 25 μM | Chick embryo cardiomyocytes and MCF-7 cells | 1, 10, 50, or 100 μM for 24 h | [22] |
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Calceolarioside | 40 μM | H9c2 cells | 1, 2, or 5 μM for 30 h | [27] |
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23-Hydroxybetulinic acid | 0.2, 2, and 20 μM | H9c2 cells | 5 μM for 18 h | [60] |
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Isorhamnetin | 3.125 to 25 µg/mL | MCF-7, HepG2, and Hep2 cells | 1 µM for 36 h | [66] |
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Kaempferol | 5 to 50 μM | H9c2 cells | 1 μM for 24 h | [69] |
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Morin hydrate | 0.17 mM | ECV304 and HepG2 cells | 6 mM for 12 h | [77] |
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Naringenin-7-O-glucoside | 10–80 μM | H9c2 cells | 10 μM for 24 h | [83] |
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Osthole | 10–40 μM | Neonatal rat cardiomyocytes | 1 μmol for 24 h | [90] |
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Luteolin-7-O-β-D-glucopyranoside | 5, 10, and 20 μM | H9c2 cells | 20 μM for 24 h | [75] |
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Luteolin-7-O-β-D-glucopyranoside | 5–80 µM | H9c2 cells | 10 µM for 24 h | [76] |
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Vincristine | 10–30 µM | Adult mouse cardiomyocytes | 15 and 20 µg/mL for 24 h | [144] |
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Sulforaphane | 2.5 µM | H9c2 cells | 5 µg/mL for 16–18 h | [129] |
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C-Phycocyanin | 10 μM | Adult rat cardiomyocytes | 10 μM for 4, 24, and 48 h | [94] |
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Plantainoside D | 1–20 μg/mL | H9c2 cells | 1, 2, and 4 μM for 30 h | [93] |
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Sesamol | 12.5–50 μM | H9c2 cells | 1 μM for 30 min | [125] |
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Tetrahydroxystilbene glucoside | 3–300 μM | Neonatal rat cardiomyocytes | 1 μmol/L for 24 h | [143] |
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Chrysoeriol | 20 µg/mL | H9c2 cells | 1 μM for 24 h | [43] |
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Visnagin | 20 μM | Neonatal rat and zebrafish cardiomyocytes, cardiac HL-1 cells | 100 μM for 48 h | [146] |
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Z-Guggulsterone | 1–30 μM | H9C2 cells | 1 μM for 24 h | [143] |
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Tanshinone IIA | 0.1, 0.3, 1, and 3 μM | Neonatal rat cardiomyocytes | 1 μM for 24 h | [134] |
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Tanshinone IIA | 1.6–40 μM | H9c2 cells | 1 μM for 24 h | [133] |
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Tanshinone IIA | 0.5, 1, and 2 μmol/L | Neonatal rat cardiomyocytes | 1 μmol/L for 24 h | [132] |
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Sodium tanshinone IIA sulphonate | 0.05–0.5 mM | Mice heart mitochondria | 0.2 mmol for 10 min | [131] |
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Anthocyanidins and anthocyanins | 0–100 μM | H9c2 cells and MCF-7 cells | 1 μM for 24 h | [14] |
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Caffeic, chlorogenic, and rosmarinic acid | 100 and 200 µM | Rat heart microsomes and mitochondria | 100 μM for 8 h | [116] |
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