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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 5806057, 6 pages
http://dx.doi.org/10.1155/2016/5806057
Review Article

Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis

Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China

Received 18 February 2016; Revised 25 April 2016; Accepted 25 May 2016

Academic Editor: Xiao-Kang Li

Copyright © 2016 Yijun Zheng and Duming Zhu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. S. Martin, D. M. Mannino, S. Eaton, and M. Moss, “The epidemiology of sepsis in the United States from 1979 through 2000,” New England Journal of Medicine, vol. 348, no. 16, pp. 1546–1554, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. J. A. Russell, “Management of sepsis,” The New England Journal of Medicine, vol. 355, no. 16, pp. 1699–1713, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. I. Ohsawa, M. Ishikawa, K. Takahashi et al., “Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals,” Nature Medicine, vol. 13, no. 6, pp. 688–694, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Zhang, Q. Wu, S. Song et al., “Effect of hydrogen-rich water on acute peritonitis of rat models,” International Immunopharmacology, vol. 21, no. 1, pp. 94–101, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. K. Xie, Y. Yu, Y. Pei et al., “Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release,” Shock, vol. 34, no. 1, pp. 90–97, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. W. Liu, L.-P. Shan, X.-S. Dong, X.-W. Liu, T. Ma, and Z. Liu, “Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury,” World Journal of Gastroenterology, vol. 19, no. 4, pp. 492–502, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Zhou, Y. Chen, G.-Q. Huang et al., “Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture,” Journal of Surgical Research, vol. 178, no. 1, pp. 390–400, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Liu, K. Xie, H. Chen et al., “Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis,” Brain Research, vol. 1589, pp. 78–92, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Liu, K. Xie, H. Chen, X. Dong, G. Wang, and Y. Yu, “Role of Nrf2 in the protective effects of hydrogen against cerebral dysfunction in septic mice,” Chinese Critical Care Medicine, vol. 26, no. 9, pp. 629–633, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Xie, W. Fu, W. Xing et al., “Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis,” Shock, vol. 38, no. 6, pp. 656–663, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. G.-M. Li, M.-H. Ji, X.-J. Sun et al., “Effects of hydrogen-rich saline treatment on polymicrobial sepsis,” Journal of Surgical Research, vol. 181, no. 2, pp. 279–286, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Xie, Y. Yu, Y. Huang et al., “Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis,” Shock, vol. 37, no. 5, pp. 548–555, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. W. Liu, X.-S. Dong, Y.-Q. Sun, and Z. Liu, “A novel fluid resuscitation protocol: provide more protection on acute kidney injury during septic shock in rats,” International Journal of Clinical and Experimental Medicine, vol. 7, no. 4, pp. 919–926, 2014. View at Google Scholar · View at Scopus
  14. H. Chen, K. Xie, H. Han et al., “Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway,” International Immunopharmacology, vol. 28, no. 1, pp. 643–654, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. B. J. Dixon, J. Tang, and J. H. Zhang, “The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance,” Medical Gas Research, vol. 3, no. 1, p. 10, 2013. View at Publisher · View at Google Scholar
  16. H. Liu, X. Liang, D. Wang et al., “Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury,” Shock, vol. 43, no. 5, pp. 504–511, 2015. View at Publisher · View at Google Scholar · View at Scopus