High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate Cancer

Figure 1

Comparative structure and expression of human HMGB proteins. (a) The HMG box folding characteristic of HMGB proteins showing the two Cys that form the disulphide bond. (b) CLUSTAL alignment of the human HMGB proteins. The three alpha-helix-stretches of HMG box-A and Box-B are indicated by their secondary structure; the acidic tail in the carboxylic end is signalled in red; cysteines are in green; the two NLSs characterized in HMGB1 are underlined in yellow. (c) Levels of expression of mRNAs from HMGB proteins are according to data from BioGPS (http://BioGPS.org).

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