Mitochondrial Alterations in Peripheral Mononuclear Blood Cells from Alzheimer’s Disease and Mild Cognitive Impairment Patients

Figure 2

Mitochondrial protein activity in PBMCs derived from AD, MCI patients and healthy controls. Cytochrome C oxidase (a) and citrate synthase (b) activity was measured spectrophotometrically (see Section 2). The data were expressed as μmole of enzyme produced/mL/min for citrate synthase activity and as units of enzyme oxidized/mL/min for cytochrome C oxidase. (c) Ratio between cytochrome C oxidase (cox) and citrate synthase (cs) was expressed as median ± SEM. The statistical significance was represented by the asterisks as follows: ; versus corresponding control group.

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