A Case-Control Study of Involvement of Oxidative DNA Damage and Alteration of Antioxidant Defense System in Patients with Basal Cell Carcinoma: Modulation by Tumor Removal
Table 2
Comparison of urinary oxidative DNA damage levels and plasma antioxidant defense status between control subjects and BCC patients.
Parameters
Controls ()
Cases ()
Before surgery
1 month after surgery
Before surgery
1 month after surgery
6 months after surgery
8-oxo-dGuo (ng/mg creatinine)
61.92 ± 17.35
71.51 ± 16.68
110.08 ± 30.09
106.65 ± 26.17
64.44 ± 19.02
CAT (unit/mg protein)
4.38 ± 0.80
3.96 ± 0.68
2.55 ± 0.43
4.34 ± 1.13
GPx (unit/mg protein)
0.77 ± 0.20
0.77 ± 0.21
0.42 ± 0.13
0.75 ± 0.11
NQO1 (µmole DCPIP reduced/min/mg protein)
928.25 ± 203.20
977.87 ± 184.54
708.53 ± 112.66
1010.30 ± 281.00
Total SOD (unit/mg protein)
0.02 ± 0.01
0.02 ± 0.00
0.04 ± 0.01
0.04 ± 0.01
GSH (µmol/mg protein)
152.19 ± 44.88
156.92 ± 40.41
235.76 ± 42.75
220.93 ± 52.44
Results were expressed as mean ± standard deviation (SD). compared to control, before surgery. compared to case, before surgery.
