A Case-Control Study of Involvement of Oxidative DNA Damage and Alteration of Antioxidant Defense System in Patients with Basal Cell Carcinoma: Modulation by Tumor Removal

Table 3

Expressions of oxidative DNA damage, DNA repair enzyme, and antioxidant proteins in skin tissues of control subjects and BCC patients by IRS.

Parameters	Controls ()	Cases ()
	Epidermis	BCC	Adjacent epidermis
8-oxo-dGuo	2.30 ± 0.67	2.88 ± 0.30	2.27 ± 0.72
hOGG1	2.56 ± 0.47	1.77 ± 0.40	2.53 ± 0.47
CAT	1.79 ± 0.63	1.18 ± 0.74	2.00 ± 0.48
GCLC	2.17 ± 0.57	1.59 ± 0.56	2.70 ± 0.45
GPx	2.02 ± 0.37	1.24 ± 0.51	1.73 ± 0.41
Nrf2	2.40 ± 0.57	1.53 ± 0.47	2.33 ± 0.44
MnSOD	1.95 ± 0.53	1.41 ± 0.65	2.60 ±  0.46

Results were expressed as mean ± standard deviation (SD).
, , compared to epidermis of control.
, compared to BCC lesion.