Alternatively Spliced Methionine Synthase in SH-SY5Y Neuroblastoma Cells: Cobalamin and GSH Dependence and Inhibitory Effects of Neurotoxic Metals and Thimerosal

<div>Domain structure and exon composition of cobalamin-dependent MS. MS is comprised of five domains: (a) HCY-binding (pink), methylfolate-binding (green), cap (yellow), cobalamin-binding (red), and SAM-binding (blue). Structures from<i> E. coli</i>  and<i> T. maritima</i>  (PDB codes 1Q8J, 1K98, and 1MSK, resp.) were used for this composite model. A structurally uncharacterized linker segment between the folate and cap domains is absent. (b) Human MS contains 33 exons specifying the five domains in a sequential manner. PCR sequences used in this study are indicated by red and black line segments.</div>

Oxidative Medicine and Cellular Longevity

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Figure 1: Alternatively Spliced Methionine Synthase in SH-SY5Y Neuroblastoma Cells: Cobalamin and GSH Dependence and Inhibitory Effects of Neurotoxic Metals and Thimerosal 

Figure 1 | Alternatively Spliced Methionine Synthase in SH-SY5Y Neuroblastoma Cells: Cobalamin and GSH Dependence and Inhibitory Effects of Neurotoxic Metals and Thimerosal 